A cranial bone reconstruction with bioactive fibre-reinforced custom-made composite implant was performed on 12 patients aged between 26 and 78 years. The reasons for craniotomies were traumatic and spontaneous intracranial bleeding, tumours and infections to the primary reconstruction material. The implant consisted of porous fibre-reinforced polymer composite with S53P4 bioactive glass granules.
Sutures or screws were used as fixation devices. The post-operative follow-up times of the longitudinal clinical study varied between 6 months and 4 years. The clinical outcomes of the study were encouraging. Both functional and aesthetic results were excellent. Normal wound healing was observed and the implants retained their positions. No local or systematic inflammatory reactions or acute systemic toxicity caused by the implant were observed. No implant-induced infections or bone resorption were detected either during the follow-up time.