Clinical Experience on Bioactive Glass S53P4 in Reconstructive Surgery in the Upper Extremity Showing Bone Remodelling, Vascularization, Cartilage Repair and Antibacterial Properties of S53P4.

Lindfors NC

A long-term clinical study of benign bone tumor treatment in upper extremities was conducted. The mean age of 9 patients was 39 years. The patients were randomized into two groups: treatment with S53P4 bioactive glass granules or with autogenous bone harvested from the iliac crest. No radiological difference between two groups was observed at 18 months. No material-related adverse reactions were observed at the long-term follow-up period of 14 years. A thickened cortex was found in case of the bioactive glass treatment.

An intra-articular condylar open fracture in a child was treated with S53P4 bioactive glass. A histopathological examination confirmed vascularization of the treated region at 3 months.

S53P4 bioactive glass was used in a re-operation of an infected comminuted olecranon fracture. The pathogen was S epidermidis. No re-infection was observed during a follow-up time of 6 months.